The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate.

The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate.

Blog Article

Homeostasis of most adult tissues is Rangehood Aluminium Filter maintained by balancing stem cell self-renewal and differentiation, but whether post-transcriptional mechanisms can regulate this process is unknown.Here, we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin.In the epidermis, this methyltransferase is found in a defined sub-population of hair follicle stem cells Massage Rollers poised to undergo lineage commitment, and its depletion results in enhanced quiescence and aberrant stem cell differentiation.

Our results reveal that post-transcriptional RNA methylation can play a previously unappreciated role in controlling stem cell fate.